Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ictal EEG changes with corpus callosum section

S S Spencer1, A Katz, J Ebersole

  • 1Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510.

Epilepsia
|May 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel retro-inverso gonadotropin-releasing hormone (GnRH) immunogen elicits antibodies that neutralize the activity of native GnRH.

Endocrinology·2003
Same author

Noninvasive native fluorescence imaging of head and neck tumors.

Technology in cancer research & treatment·2003
Same author

Variation in the DCP1 gene, encoding the angiotensin converting enzyme ACE, is not associated with increased susceptibility to Alzheimer's disease.

Psychiatric genetics·2003
Same author

Therapeutic potential of curcumin in human prostate cancer-I. curcumin induces apoptosis in both androgen-dependent and androgen-independent prostate cancer cells.

Prostate cancer and prostatic diseases·2002
Same author

Interpretation of spring recession curves.

Ground water·2002
Same author

Ideal vitamin C intake.

BioFactors (Oxford, England)·2002

Corpus callosum sectioning reduces but doesn't eliminate interictal EEG discharges. However, it significantly disrupts bilateral synchronous seizure onset, suggesting the corpus callosum is crucial for generalized seizure spread.

Area of Science:

  • Neuroscience
  • Epileptology
  • Neurosurgery

Background:

  • Corpus callosum sectioning is used to treat epilepsy.
  • Its effect on interictal EEG discharges is known, but ictal patterns remain undescribed.

Purpose of the Study:

  • To investigate the impact of corpus callosum sectioning on ictal electroencephalogram (EEG) patterns.
  • To differentiate the roles of the corpus callosum in interictal vs. ictal discharges.

Main Methods:

  • Compared ictal EEG patterns before and after anterior callosotomy (18 patients) and total callosotomy (10 patients).
  • Analyzed changes in seizure onset synchrony and localization.

Main Results:

  • Anterior and total callosotomy disrupted bilaterally synchronous seizure onset in a significant proportion of patients.

Related Experiment Videos

  • Post-procedure, more localized seizure onsets were observed, including new posterior localizations after total section.

    • Conclusions:

    • The corpus callosum appears to be the primary pathway for generating apparent bilateral synchronous seizure onset in secondarily generalized seizures.
    • Mechanisms for interictal and ictal bilateral synchrony likely differ, with brainstem/diencephalic structures potentially involved in interictal synchrony.