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1H and 15N assignments and secondary structure of the Src SH3 domain
H Yu1, M K Rosen, S L Schreiber
1Department of Chemistry, Harvard University, Cambridge, MA 02138.
FEBS Letters
|June 7, 1993
Abstract:
The 1H and 15N sequential assignments of the Src SH3 domain have been determined through a combination of 2D and 3D Nuclear Magnetic Resonance (NMR) methods. The secondary structure of the protein has been identified based on long-range NOE patterns. The SH3 domain of Src consists largely of six beta-strands that form two anti-parallel beta-sheets.