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Related Experiment Videos

Alexander's disease: clues to diagnosis

C L Pridmore1, M Baraitser, B Harding

  • 1Department of Paediatric Neurology, Hospital for Sick Children, London, England.

Journal of Child Neurology
|April 1, 1993
PubMed
Summary

Alexander's disease in children presents two main forms: infantile with macrocephaly and seizures, and juvenile with predominant bulbar signs. Diagnosis relies on combined findings, necessitating histologic confirmation.

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Area of Science:

  • Pediatric Neurology
  • Neurodegenerative Disorders
  • Genetic Diseases

Background:

  • Alexander's disease is a rare, progressive, demyelinating disorder of the central nervous system.
  • It is characterized by the presence of Rosenthal fibers in white matter.