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[Calculi and sludge in the gallbladder during pregnancy]
M Giangrande1, F Russo, A Coviello
1Divisione di Ostetricia e Ginecologia, IRCCS S. De Bellis, Castellana G., Bari.
Minerva Ginecologica
|April 1, 1993
Summary
Gallbladder sludge and gallstones are common in pregnant women, with many cases resolving postpartum. This study tracked their incidence and natural history in a rural population.
Area of Science:
- Gastroenterology
- Obstetrics & Gynecology
- Radiology
Background:
- Gallbladder sludge and gallstones are frequently observed during pregnancy and postpartum periods.
- Previous ultrasound surveys indicate a 30-40% prevalence in examined women.
Purpose of the Study:
- To determine the incidence of biliary sludge and gallstones during pregnancy.
- To investigate the natural history of gallbladder pathology after delivery in a rural population.
Main Methods:
- Prospective ultrasound examinations were conducted on 56 pregnant women during the first trimester, third trimester, and two weeks postpartum.
- Women with biliary findings underwent a 12-month follow-up ultrasound.
- Data collected included menarche, menstrual history, obstetric history, oral contraceptive use, BMI, weight gain, and abdominal symptoms.
Main Results:
- Biliary findings were detected in 5/56 women in the first trimester (1 gallstone, 4 sludge).
- By the third trimester, 9/49 women showed biliary findings (2 gallstones, 7 sludge).
- Two weeks postpartum, 2/46 women still had gallstones.
Conclusions:
- Gallbladder sludge and gallstones are prevalent during pregnancy.
- A significant proportion of these findings may resolve spontaneously after delivery.
- Further investigation is warranted to understand the long-term natural history and risk factors in rural populations.