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Developmental expression of trkB and low-affinity NGF receptor in the rat retina
J B Takahashi1, M Hoshimaru, H Kikuchi
1Department of Viral Oncology, Kyoto University, Japan.
Neuroscience Letters
|March 19, 1993
Abstract:
Brain-derived neurotrophic factor (BDNF) promotes the survival of retinal ganglion cells, but these effects are dependent on the developmental stages, and a number of retinal ganglion cells are eliminated during pre- and neonatal stages. We have examined the expression of BDNF receptors, trkB and low-affinity nerve growth factor receptor (LNGFR), in the rat retina during these period using Northern blot analysis. The expression of trkB and LNGFR displayed two peaks during embryonic day 17 (E17) through postnatal day 1 (P1), and during P14-P17, indicating that it may play an important role in neuronal development and neuronal cell death.