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Related Experiment Videos

Zinc, copper and oxalocalcic urolithiasis

F Grases1, J Ruiz, A Costa-Bauzá

  • 1Department of Chemistry, University of the Balearic Islands, Palma de Mallorca, Spain.

Urologia Internationalis
|January 1, 1993
PubMed
Summary

This study investigated zinc (Zn) and copper (Cu) in calcium oxalate stones. While these minerals affected crystal formation, they likely do not directly cause oxalocalcic urolithiasis.

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Area of Science:

  • Biochemistry
  • Urology
  • Mineral Metabolism

Background:

  • Oxalocalcic urolithiasis is a common kidney stone condition.
  • The role of trace elements like zinc (Zn) and copper (Cu) in stone formation is not fully understood.

Purpose of the Study:

  • To investigate the effects of Zn and Cu on calcium oxalate crystal formation.
  • To compare urinary and serum levels of Zn and Cu in stone formers versus healthy individuals.

Main Methods:

  • In vitro analysis of calcium oxalate crystal morphology in the presence of Zn and Cu.
  • Measurement of urinary and serum Zn and Cu concentrations in human cohorts.

Main Results:

  • Zn and Cu ions altered calcium oxalate crystal morphology and increased primary aggregation at higher concentrations.
  • Urinary Zn levels were lower in stone formers than healthy individuals.
  • Urinary Cu levels were lower in male stone formers than healthy males, but similar in females.

Conclusions:

  • Zn and Cu influence calcium oxalate crystal formation in vitro.
  • Observed differences in urinary Zn and Cu levels between groups diminished when serum levels were considered.
  • No significant direct role for Zn and Cu in the genesis of oxalocalcic calculi is suggested by these findings.

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