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High-molecular-weight hydroxypropylmethylcellulose. A cholesterol-lowering agent
J B Dressman1, C H Adair, J L Barnett
1College of Pharmacy, University of Michigan, Ann Arbor.
Archives of Internal Medicine
|June 14, 1993
Summary
High-molecular-weight hydroxypropylmethylcellulose effectively lowers cholesterol, particularly LDL cholesterol, in normal and hyperlipidemic adults. This agent demonstrates a favorable dose-response profile and good tolerability for treating mild hypercholesterolemia.
Area of Science:
- Biochemistry
- Clinical Pharmacology
Background:
- Investigating high-molecular-weight hydroxypropylmethylcellulose (K8515) as a cholesterol-lowering agent.
- Assessing the dose-response relationship and tolerability of K8515.
Purpose of the Study:
- To evaluate the efficacy of K8515 in reducing cholesterol levels.
- To determine the optimal dosage and assess patient tolerance.
Main Methods:
- Double-blind, randomized crossover trials in normal and hyperlipidemic subjects.
- Dose-response studies with escalating doses in hypercholesterolemic subjects.
- Tolerance assessed via questionnaires on adverse effects and bowel habits.
Main Results:
- 10g K8515 three times daily lowered total cholesterol by 32% in normal subjects and 18-20% in hyperlipidemic subjects within one week.
- Significant reductions in low-density lipoprotein (LDL) cholesterol were observed.
- A 15% LDL reduction was achievable with 6.7g K8515 three times daily with minimal adverse effects.
Conclusions:
- High-molecular-weight hydroxypropylmethylcellulose shows promise for clinical use.
- K8515 is effective in managing mild hypercholesterolemia.
- The agent is well-tolerated at effective doses.