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[Arterial lesions after radiotherapy in children. Apropos of 16 cases]
O Ganry1, J L Habrand, J Lemerle
1Département de Radiothérapie, l'Institut Gustave-Roussy, Villejuif.
Background:
Arterial occlusive disease is an uncommon and rather unpredictable complication of radiotherapy in childhood.
Case Reports:
Sixteen children (10 under 5 years of age and 7 under 3 years of age) who underwent radiotherapy for tumors between 1967 and 1983 developed an arterial occlusion with clinical manifestations during their follow-up. The radiotherapy dose was 25-55 Gy, and the fractionation was "conventional". The clinical manifestations depended on the site of arterial stenosis, including aorta and/or its branches (11 cases), carotid artery (3 cases) and limb arteries (2 cases). The delay before onset of clinical manifestations was variable, but generally very long (median: 13 years). Eight patients required surgical rehabilitation.
Conclusion:
Better management of this type of complication should benefit from the early screening of irradiated children, especially young children, given even moderate doses, and particularly those having received more than 40 Gy.