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Phylogeny of B-cell development

L Du Pasquier1

  • 1Basel Institute for Immunology, Switzerland.

Current Opinion in Immunology
|April 1, 1993
PubMed
Summary
This summary is machine-generated.

All jawed vertebrates possess B cells that undergo somatic rearrangement of immunoglobulin (Ig) genes for antibody diversity. Differences in antibody repertoires across species may stem from variations in somatic mutation selection and gene organization.

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Area of Science:

  • Immunology
  • Evolutionary Biology
  • Genetics

Background:

  • B cells are crucial for adaptive immunity in all jawed vertebrates (Gnathostomata).
  • Immunoglobulin (Ig) gene organization and rearrangement vary significantly across vertebrate species.
  • Somatic diversification of Ig genes is a fundamental process for generating antibody diversity.

Purpose of the Study:

  • To investigate the conserved and divergent mechanisms of B cell immunoglobulin gene rearrangement and diversification across vertebrates.
  • To explore how variations in these processes contribute to differences in antibody repertoires among species.
  • To understand the impact of germinal center presence on somatic mutant selection and repertoire development.

Main Methods:

  • Comparative analysis of immunoglobulin gene organization and rearrangement across diverse vertebrate species.

Related Experiment Videos

  • Examination of somatic diversification mechanisms, including junctional diversity and somatic mutation (gene conversion).
  • Assessment of B cell repertoire development in early life stages and its relation to N-region diversity and gene segment usage.

    • Main Results:

    • All Gnathostomata possess B cells that somatically rearrange Ig genes, with exceptions in some cartilaginous fish.
    • Somatic diversification occurs universally through junctional diversity and somatic mutation.
    • Poor selection of somatic mutants in species lacking germinal centers correlates with antibody repertoire differences.
    • Early B cell repertoires are restricted due to limited N-region diversity and specific D segment usage.

    Conclusions:

    • Somatic Ig gene rearrangement is a conserved B cell feature across jawed vertebrates.
    • Variations in germinal center-mediated selection and gene organization shape species-specific antibody repertoires.
    • Developmental factors like N-region diversity significantly influence the early B cell repertoire in all studied species.