Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

EGF: new tricks for an old growth factor

G Carpenter¹

¹Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232-0146.

Current Opinion in Cell Biology

|April 1, 1993

Summary

Researchers explored epidermal growth factor (EGF) biology in simple organisms. They discovered EGF-like gene mutations cause defects and identified EGF receptors

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mineral reaction kinetics constrain the length scale of rock matrix diffusion.

Scientific reports·2020

Same author

Composition of enamel pellicle from dental erosion patients.

Caries research·2014

Same author

Comparison of the possible protective effect of the salivary pellicle of individuals with and without erosion.

Caries research·2013

Same author

Tuberculosis of the Choroid: A Further Contribution.

British medical journal·2010

Same author

The Wightman Lecture ON CONGENITAL HEART AFFECTIONS, ESPECIALLY IN RELATION TO THE DIAGNOSIS OF THE VARIOUS MALFORMATIONS: Delivered before the Royal Society of Medicine, Section of Diseases of Children.

British medical journal·2010

Same author

[Hypoplastic anemia with immaturity of the marrow].

Annals of western medicine and surgery·2010

Area of Science:

Molecular Biology
Genetics
Microbiology

Background:

Epidermal growth factor (EGF) signaling is crucial in multicellular organisms.
Investigating EGF in simpler systems can reveal fundamental biological roles.

Purpose of the Study:

To explore the conserved functions of epidermal growth factor (EGF) and its signaling pathways in lower organisms.
To identify novel roles for EGF-like molecules beyond typical mammalian systems.

Main Methods:

Comparative genomics and genetic analysis in model organisms like *C. elegans* and *Drosophila*.
Biochemical assays to study interactions between bacterial components and host cell receptors.

Main Results:

Mutations in EGF-like genes in *C. elegans* and *Drosophila* led to identifiable developmental defects.
EGF receptors were found to play a role in the invasion mechanisms of certain bacteria.
EGF-like precursors function as receptors for bacterial toxins.

Conclusions:

EGF signaling pathways possess conserved functions across diverse organisms, including invertebrates and bacteria.
EGF-like molecules have multifaceted roles, extending to host-pathogen interactions and toxin reception.

Related Experiment Videos