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Expression of E-cadherin in embryogenetic ingression and cancer invasion
M Mareel1, M Bracke, F Van Roy
1Department of Radiotherapy and Nuclear Medicine, University Hospital, Ghent, Belgium.
The International Journal of Developmental Biology
|March 1, 1993
Abstract:
Homophilic interactions of E-cadherin serve the organization of embryonic and adult epithelia and counteract cancer invasion. The role of E-cadherin as an invasion-suppressor molecule has been demonstrated cancer. Regulation of embryonic ingression and cancer invasion via E-cadherin occurs at transcriptional, translational and post-translation levels.