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Congenital nephrogenic diabetes insipidus in an adult
1Third Department of Internal Medicine, Fukushima Medical College, Japan.
Internal Medicine (Tokyo, Japan)
|February 1, 1993
Abstract:
A 35-year-old man with congenital nephrogenic diabetes insipidus (NDI) is reported. Renal biopsy revealed miniaturized and rounded mitochondria of the proximal tubular cells and decreased brush-borders. Trichlormethiazide combined with triamterene resulted in an apparent reduction of daily urine volume and concomitant increment in urine osmolarity. The present case seems rare in that some morphological changes in the renal tissues could be demonstrated in an adult case with congenital NDI.