Related Experiment Videos
Malignant lymphoma with myxoid change and sarcomatous features
A Nonomura1, Y Mizukami, T Hirone
1Pathology Section, Kanazawa University Hospital, School of Medicine, Kanazawa University, Japan.
Internal Medicine (Tokyo, Japan)
|February 1, 1993
Summary
This case highlights an unusual B-cell malignant lymphoma presenting with kidney and mediastinal involvement. Immunohistochemistry was crucial for diagnosing this rare lymphoma with myxoid and sarcomatous features.
Area of Science:
- Oncology
- Pathology
- Immunohistochemistry
Background:
- Malignant lymphomas can present with diverse histologic features.
- Extranodal involvement, particularly in the kidney and mediastinum, requires careful diagnostic consideration.
Observation:
- A case presented with renal and mediastinal masses exhibiting prominent myxoid changes and sarcomatous features on routine histology.
- Initial histologic examination posed diagnostic challenges due to the unusual morphology.
Findings:
- Immunohistochemical staining for lymphocyte markers confirmed the diagnosis of B-cell malignant lymphoma.
- The presence of myxoid stroma, though uncommon, was noted in this malignant lymphoma.
Implications:
- Malignant lymphoma should be considered in the differential diagnosis of small round cell sarcomas with myxoid stroma.
- Immunohistochemistry is vital for accurate histologic diagnosis in challenging lymphoma cases, especially with extranodal soft tissue involvement.