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Related Experiment Videos

Hematuria and sickle cell disorders

E L Lewis, J R Ross, J H Cohn

    Southern Medical Journal
    |April 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Gross hematuria is uncommon in sickle cell disease but can occur in sickle cell trait. Conservative treatment is typically effective for managing this condition in affected individuals.

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    Area of Science:

    • Nephrology
    • Hematology
    • Genetics

    Background:

    • Sickle cell disorders encompass sickle cell disease and sickle cell trait.
    • Gross hematuria, or visible blood in urine, is a potential complication.
    • Understanding the association between these conditions is crucial for patient management.

    Purpose of the Study:

    • To investigate the occurrence of gross hematuria in patients with sickle cell disorders.
    • To determine if gross hematuria is associated with sickle cell disease or sickle cell trait.

    Main Methods:

    • Retrospective review of patients admitted with sickle cell disorders over 14 months.
    • Analysis of patient demographics, diagnosis (disease vs. trait), and presence of gross hematuria.
    • Comprehensive examinations and laboratory studies to rule out other causes.

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    Main Results:

    • Of 115 patients, 65% had sickle cell disease and 35% had sickle cell trait.
    • Gross hematuria was observed in seven patients, all of whom had sickle cell trait.
    • No patients with sickle cell disease presented with gross hematuria.
    • These seven patients were free of other diseases and averaged 30 years of age.

    Conclusions:

    • Gross hematuria in the context of sickle cell disorders appears to be specifically associated with sickle cell trait.
    • Conservative management, including hydration and bed rest, is generally effective.
    • Further research may elucidate the precise mechanisms linking sickle cell trait to gross hematuria.