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Methylprednisolone reduces excitatory amino acid release following experimental spinal cord injury
1Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77555.
Brain Research
|April 23, 1993
Abstract:
Administration of methylprednisolone within several hours after injury to the spinal cord has been shown to reduce subsequent impairment in humans and experimental animals. Secondary damage following initial trauma is probably caused in part by the toxicity of released excitatory amino acids. We demonstrate here that methylprednisolone reduces the release of excitatory amino acids following experimental spinal cord injury in rats.

