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Treatment-related esophageal stricture in pediatric patients with cancer
J D Ellenhorn1, A Lambroza, K L Lindsley
1Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Background:
Intensive antineoplastic regimens have enhanced long-term survival in pediatric patients with cancer, but can result in long-term complications. Esophageal stricture formation is one such complication.
Methods:
We reviewed the experience with benign esophageal stricture in pediatric patients with cancer over the past 15 years in a major cancer center. Clinical course, along with endoscopic, radiologic, and manometric esophageal studies, was reviewed.
Results:
Esophageal strictures formed in five pediatric patients who were treated with radiation and/or chemotherapy. Stricture formation was associated with abnormal esophageal motility in four out of the five patients. Repeated esophageal dilation was performed from 3-50 times and resulted in stricture resolution in only 2 of the 5 patients.
Conclusions:
Esophageal stricture formation in this population is rare, but is associated with long-term morbidity.