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Related Experiment Videos

Hypercalcemia complicating childhood malignancies

C McKay1, W L Furman

  • 1Division of Nephrology, College of Medicine, University of Tennessee, Memphis.

Cancer
|July 1, 1993
PubMed
Summary
This summary is machine-generated.

Hypercalcemia in childhood cancer is rare, affecting 0.4% of patients. Acute lymphoblastic leukemia cases presented earlier and resolved, unlike solid tumors which were more resistant to therapy.

Related Experiment Videos

Area of Science:

  • Pediatric Oncology
  • Oncologic Emergencies
  • Calcium Metabolism

Background:

  • Hypercalcemia is a common complication of malignancy in adults.
  • Limited data exists on the pathogenesis and incidence of hypercalcemia in pediatric cancer patients.

Purpose of the Study:

  • To determine the incidence of hypercalcemia in children with cancer.
  • To analyze the timing of presentation and response to therapy for hypercalcemia in pediatric malignancies.

Main Methods:

  • Retrospective study of pediatric cancer patients diagnosed with hypercalcemia.
  • Analysis of data over a 29-year period at St. Jude Children's Research Hospital.

Main Results:

  • 25 children (0.4% of total pediatric cancer patients) were diagnosed with hypercalcemia over 29 years.
  • Acute leukemias (0.6%) and rhabdomyosarcoma (1.2%) were among the most common associated malignancies.
  • Solid tumors presented with hypercalcemia later and showed more resistance to treatment.

Conclusions:

  • Hypercalcemia of malignancy is rare in children, contrasting with adult populations.
  • Acute lymphoblastic leukemia patients were more likely to present with and resolve hypercalcemia.
  • Solid tumors in children presented later with hypercalcemia that was more resistant to therapy.