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Chronic bile diversion does not alter canine interdigestive myoelectric activity
S J Hughes1, K E Behrns, M G Sarr
1Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905.
Digestive Diseases and Sciences
|June 1, 1993
Summary
Bile entering the duodenum during fasting does not regulate gut motility or motilin hormone release. This study found no significant changes in migrating myoelectric complexes or motilin levels after altering bile duct entry.
Area of Science:
- Gastroenterology
- Physiology
Background:
- Previous research suggested cyclic bile entry into the duodenum regulates interdigestive motility via motilin.
- The role of bile in regulating gut motility and hormone release requires further investigation.
Purpose of the Study:
- To investigate if cyclic bile secretion into the duodenum regulates interdigestive myoelectric activity.
- To determine the effect of bile on plasma motilin concentrations during fasting.
Main Methods:
- Utilized six dogs equipped with gastric and intestinal serosal electrodes to measure myoelectric activity.
- Compared motility patterns and plasma motilin levels before and after surgically redirecting the bile duct entrance to the mid-jejunum.
- Analyzed the characteristics of the migrating myoelectric complex (MMC) and postprandial pattern conversion.
Main Results:
- No significant alterations were observed in MMC characteristics (period, phase III velocity, phase duration) after bile duct translocation.
- Plasma motilin concentrations remained similar and continued to cycle with the MMC, peaking during phase III, irrespective of bile duct position.
- Chronic diversion of bile from the duodenum did not affect interdigestive myoelectric patterns or cyclic motilin release.
Conclusions:
- The presence of bile in the duodenal lumen does not regulate interdigestive myoelectric patterns in the canine upper gut.
- Cyclic release of motilin is independent of bile presence in the duodenum during fasting.