Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diastolic failure: pathophysiology and therapeutic implications

D L Brutsaert1, S U Sys, T C Gillebert

  • 1Department of Physiology and Medicine, Antwerp University, Belgium.

Journal of the American College of Cardiology
|July 1, 1993
PubMed
Summary

Primary diastolic dysfunction, a heart failure type, stems from impaired ventricular filling, causing exercise intolerance. Therapy involves addressing causes like abnormal heart rate and relaxation, using specific medications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Atrial fibrillation cycle length and atrial size in horses with and without recurrence of atrial fibrillation after electrical cardioversion.

Journal of veterinary internal medicine·2014
Same author

Modest opposite associations of endogenous testosterone and oestradiol with left ventricular remodelling and function in healthy middle-aged men.

International journal of andrology·2011
Same author

Determining carotid artery pressure from scaled diameter waveforms: comparison and validation of calibration techniques in 2026 subjects.

Physiological measurement·2008
Same author

Identification and validation of housekeeping genes as internal control for gene expression in an intravenous LPS inflammation model in chickens.

Veterinary immunology and immunopathology·2008
Same author

Validation of a new automated IMT measurement algorithm.

Journal of human hypertension·2007
Same author

Air contact influences the pH of extended porcine semen.

Reproduction in domestic animals = Zuchthygiene·2007

Area of Science:

  • Cardiology
  • Heart Failure Pathophysiology

Background:

  • Diastolic dysfunction is a primary pathophysiologic entity.
  • It leads to increased resistance to ventricular filling.
  • This results in an upward shift of the diastolic pressure-volume relation, especially during exercise.

Purpose of the Study:

  • To define primary diastolic dysfunction.
  • To identify its causes and pathophysiologic mechanisms.
  • To outline therapeutic strategies.

Main Methods:

  • Conceptual distinction between impaired systolic relaxation and compensatory prolonged systolic contraction.
  • Analysis of factors contributing to diastolic failure.
  • Consideration of disease type, phase, and compensatory processes for treatment.

Related Experiment Videos

Main Results:

  • Primary diastolic dysfunction is characterized by increased resistance to ventricular filling.
  • Key causes include inappropriate tachycardia, decreased diastolic compliance, and impaired systolic relaxation.
  • Exercise intolerance is a prominent symptom.

Conclusions:

  • Optimal therapy for diastolic dysfunction is individualized.
  • Treatment depends on the specific disease, its stage, and compensatory mechanisms.
  • Therapeutic options include bradycardic, remodeling, and lusitropic drugs.