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Published on: December 19, 2014
Defective phagocytosis in chronic trichophytosis
T Gregurek-Novak1, S Rabatić, V Silobrcić
1Dermatovenerological Clinic, Clinical Hospital Sestre Milosrdnice, Croatia, Zagreb.
Summary
Primary chronic trichophytosis (PCT) in Croatia is often caused by Trichophyton interdigitale. This study found that PCT patients exhibit defective phagocytosis in their peripheral blood leukocytes, suggesting an immune system link.
Area of Science:
- Dermatology
- Immunology
- Mycology
Background:
- Primary chronic trichophytosis (PCT) is an emerging clinical diagnosis.
- The anthropophilic fungus Trichophyton interdigitale is the main cause of PCT in Croatia.
- Immunological defects may contribute to the chronicity of PCT.
Purpose of the Study:
- To investigate potential immunological defects in patients with PCT.
- To compare immune parameters in PCT patients with healthy controls.
- To identify the specific immune mechanisms underlying chronic trichophytosis.
Main Methods:
- Studied 62 patients diagnosed with PCT.
- Performed skin testing and quantified T- and B-lymphocytes.
- Assessed immunoglobulin classes and leukocyte phagocytosis (mobility, ingestion, digestion, killing).
Main Results:
- Patients with PCT demonstrated significantly defective phagocytosis (P < 0.001).
- Defects were observed in random mobility, ingestion, and digestion by leukocytes.
- T- and B-lymphocyte counts and immunoglobulin levels were within normal ranges compared to controls.
Conclusions:
- Primary chronic trichophytosis is associated with impaired phagocytic function of peripheral blood leukocytes.
- Defective phagocytosis appears to be a key factor in the chronicity of trichophytosis.
- Further research into leukocyte function is warranted for understanding and managing PCT.
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