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The CUB domain. A widespread module in developmentally regulated proteins

P Bork1, G Beckmann

  • 1EMBL, Heidelberg, Germany.

Journal of Molecular Biology
|May 20, 1993
PubMed
Summary

Researchers identified a new protein domain family called CUB domains, finding 31 copies in 16 diverse proteins crucial for development. These domains share structural similarities with immunoglobulin structures.

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Area of Science:

  • Biochemistry
  • Developmental Biology
  • Structural Biology

Background:

  • The CUB (CRISP, WAP, DNase I, andendeuroligin) domain is an extracellular protein module.
  • CUB domains are present in diverse proteins involved in biological processes, including development.

Purpose of the Study:

  • To identify and characterize novel CUB domain-containing proteins.
  • To analyze conserved features and predict the structure of the CUB domain.

Main Methods:

  • Sequence analysis of protein databases.
  • Identification of novel CUB domain members.
  • Topology prediction of the CUB domain structure.

Main Results:

  • Identified 31 CUB domain copies within 16 functionally diverse proteins.

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  • Discovered seven previously undescribed CUB domain-containing proteins.
  • Topology prediction suggests a conserved antiparallel beta-barrel structure similar to immunoglobulins.

    • Conclusions:

    • The CUB domain is a conserved extracellular module with a predicted beta-barrel structure.
    • CUB domains are implicated in various developmental processes.
    • Further research into CUB domain function and evolution is warranted.