Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Increased reverse cholesterol transport in athletes

A K Gupta1, E A Ross, J N Myers

  • 1Cholesterol Center, Veterans Affairs Medical Center, Long Beach, Irvine, CA.

Metabolism: Clinical and Experimental
|June 1, 1993
PubMed
Summary

Athletes exhibit enhanced reverse cholesterol transport (RCT), a key mechanism for heart protection, even without elevated HDL cholesterol. This improved cholesterol metabolism in athletes is linked to increased LCAT and CETP activities, reducing cardiac risk.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peripheral edema due to nifedipine-itraconazole interaction: a case report.

Archives of dermatology·1996
Same author

High frequency 40-MHz ultrasound. A possible noninvasive method for the assessment of the boundary of basal cell carcinomas.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·1996
Same author

Effect of ionizing radiation on AP-1 binding activity and basic fibroblast growth factor gene expression in drug-sensitive human breast carcinoma MCF-7 and multidrug-resistant MCF-7/ADR cells.

The Journal of biological chemistry·1995
Same author

Role of cellular casein kinase II in the function of the phosphoprotein (P) subunit of RNA polymerase of vesicular stomatitis virus.

The Journal of biological chemistry·1995
Same author

Fundus imaging in patients with cataract: role for a variable wavelength scanning laser ophthalmoscope.

The British journal of ophthalmology·1995
Same author

Age and gender differences in the impact of psoriasis on quality of life.

International journal of dermatology·1995

Area of Science:

  • Cardiovascular Physiology
  • Lipid Metabolism
  • Exercise Science

Background:

  • Exercise confers cardioprotective benefits, partly through improved lipid deposition and reverse cholesterol transport (RCT).
  • RCT is a complex process involving cholesterol efflux, esterification, and transport to the liver for excretion.

Purpose of the Study:

  • To investigate if RCT is enhanced in athletes compared to sedentary individuals.
  • To determine if enhanced RCT occurs independently of significant increases in high-density lipoprotein cholesterol (HDL-C) levels.

Main Methods:

  • Fasting blood samples were collected from sedentary men and athletes.
  • In vitro assays measured net mass of free cholesterol transported (NMCT) from fibroblasts into serum.
  • Enzyme activities of lecithin:cholesterol acyltransferase (LCAT) and cholesterol ester transfer protein (CETP) were quantified.

Related Experiment Videos

Main Results:

  • Athletes showed significantly higher NMCT compared to controls (P = .048).
  • Despite similar HDL-C and apolipoprotein A-1 levels, athletes had lower low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apo B).
  • Athletes exhibited increased plasma LCAT (P = .028) and CETP activities (P < .001).

Conclusions:

  • Athletes possess an enhanced capacity for reverse cholesterol transport, contributing to cardioprotection.
  • This enhancement is associated with increased LCAT and CETP activities and potentially decreased cholesterol influx, not solely higher HDL-C.
  • Findings suggest a more favorable lipid profile and reduced cardiac risk in athletes due to improved RCT mechanisms.