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Crystal structure of cyclin-dependent kinase 2
H L De Bondt1, J Rosenblatt, J Jancarik
1Department of Chemistry, University of California, Berkeley 94720.
Nature
|June 17, 1993
Abstract:
Cyclin-dependent kinase 2 (CDK2) is a member of a highly conserved family of protein kinases that regulate the eukaryotic cell cycle. The crystal structures of the human CDK2 apoenzyme and its Mg2+ ATP complex have been determined to 2.4 A resolution. The structure is bi-lobate, like that of the cyclic AMP-dependent protein kinase, but contains a unique helix-loop segment that interferes with ATP and protein substrate binding and probably plays a key part in the regulation of all cyclin-dependent kinases.