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Some recent aspects of the molecular biology of human lymphoma
C J Larsen1, P Seite, J Hillion
1Unité 301 INSERM, Institut de Génétique Moléculaire, Paris, France.
Nouvelle Revue Francaise D'Hematologie
|February 1, 1993
Abstract:
Some recent aspects of the molecular biology of chromosome abnormalities that activate the BCL2 gene in B cell malignancies (follicular lymphoma, chronic lymphocytic leukemia) are discussed. We also report data showing that the Epstein-Barr virus (EBV) LMP-1 protein which can induce the expression of BCL2, is found infrequently in follicular lymphomas which exhibit no apparent BCL2 gene rearrangement.