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Related Experiment Videos

Corticosterone modulation of dietary selection patterns

M E Bligh1, L W Douglass, T W Castonguay

  • 1Department of Human Nutrition and Food Systems, University of Maryland-College Park 20742.

Physiology & Behavior
|May 1, 1993
PubMed
Summary
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Corticosterone (CORT) supplementation impacts weight gain and macronutrient selection in adrenalectomized rats. CORT influenced fat intake and consumption patterns, especially after food deprivation.

Area of Science:

  • Endocrinology
  • Nutritional Neuroscience
  • Behavioral Pharmacology

Background:

  • Adrenalectomy (ADX) in Sprague-Dawley rats significantly alters physiological responses.
  • Corticosterone (CORT) is a key glucocorticoid hormone involved in stress response and metabolism.
  • Understanding CORT's role in nutrient selection is crucial for metabolic and behavioral research.

Purpose of the Study:

  • To investigate the effects of exogenous corticosterone (CORT) supplementation on ad libitum and food-deprivation-induced macronutrient selection in male adrenalectomized (ADX) rats.
  • To determine if CORT can restore physiological parameters affected by adrenalectomy, such as weight gain and intake following deprivation.
  • To elucidate the specific impact of CORT on the selection of protein, carbohydrates, and fats.

Main Methods:

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  • Male Sprague-Dawley rats underwent adrenalectomy (ADX).
  • ADX rats self-administered varying concentrations of CORT (0, 20, 40 µg/ml).
  • Macronutrient intake (protein, carbohydrates, fat) was measured ad libitum and after 0 or 24-hour food deprivation.

Main Results:

  • Adrenalectomy reduced weight gain and protein intake, effects not fully reversed by CORT.
  • CORT supplementation (40 µg/ml) increased fat intake in ad lib conditions.
  • Following deprivation, CORT-treated rats consumed more fat, and unsupplemented ADX rats showed reduced fat and caloric intake.

Conclusions:

  • Corticosterone influences weight gain in lean rats.
  • CORT modulates macronutrient selection, particularly fat intake, in both ad libitum and food-deprived states.
  • The study highlights CORT's significant role in regulating energy balance and dietary choices.