Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adverse drug effects in relation to renal function

H Jick

    The American Journal of Medicine
    |April 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    This study examined drug toxicity and kidney function in 67 medications. Unexpectedly, few drugs showed increased toxicity with higher blood urea nitrogen levels upon admission.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Epidemiology of lower limb fractures in general practice in the United Kingdom.

    Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention·2004
    Same author

    Statin use and cancer risk in the General Practice Research Database.

    British journal of cancer·2004
    Same author

    The risk of stillbirth in pregnancies before and after the onset of diabetes.

    Diabetic medicine : a journal of the British Diabetic Association·2003
    Same author

    Statin use, hyperlipidaemia, and the risk of breast cancer.

    British journal of cancer·2002
    Same author

    Risk of venous thromboembolism with cyproterone or levonorgestrel contraceptives.

    Lancet (London, England)·2001
    Same author

    Live attenuated polio vaccine and the risk of intussusception.

    British journal of clinical pharmacology·2001

    Area of Science:

    • Pharmacology
    • Nephrology
    • Clinical Toxicology

    Background:

    • Acute drug toxicity is a significant clinical concern.
    • Renal function plays a crucial role in drug metabolism and excretion.
    • Understanding the link between renal impairment and drug toxicity is vital for patient safety.

    Purpose of the Study:

    • To investigate the relationship between acute drug toxicity and renal function.
    • To assess this relationship for 67 commonly prescribed drugs.
    • To identify drugs where renal function, specifically blood urea nitrogen levels, impacts toxicity.

    Main Methods:

    • Retrospective analysis of clinical data.
    • Inclusion of 67 commonly used drugs.
    • Assessment of drug toxicity in relation to blood urea nitrogen levels on admission.

    Related Experiment Videos

    Main Results:

    • Fewer than anticipated drugs demonstrated a positive correlation between toxicity and elevated blood urea nitrogen.
    • The majority of the 67 drugs did not show a strong link between admission blood urea nitrogen and acute toxicity.
    • Some drugs did exhibit a positive correlation, warranting further investigation.

    Conclusions:

    • The association between acute drug toxicity and elevated blood urea nitrogen is less prevalent than expected.
    • Further research is needed for drugs showing a positive correlation, considering confounding variables.
    • Clinical monitoring of renal function remains important in managing drug toxicity.