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Updated: Aug 14, 2026

Associated Chromosome Trap for Identifying Long-range DNA Interactions
Published on: April 23, 2011
Lamin A/C gene and a related sequence map to human chromosomes 1q12.1-q23 and 10
A K Kamat1, M Rocchi, D I Smith
1Department of Biochemistry and Molecular Biology, Lederle Graduate Research Center, University of Massachusetts, Amherst.
Abstract:
Lamins A and C are products of alternate splicing of one transcript from a single gene. We have isolated a partial cDNA, cE1-2, whose 800-bp sequence is 99% identical to the 3' untranslated region of the lamin A/C gene. We report here the mapping of this gene and a closely related sequence to human chromosomes 1 and 10, more specifically, to 1q12.1-q23. The localization of cE1-2 hybridizing sequences to two different chromosomes suggests that one of these loci represents an as yet unknown member of the lamin gene family, either a pseudogene or an expressed gene.
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