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Tonography in the normal and glaucomatous beagle

K N Gelatt, R M Gwin, R L Peiffer

American Journal of Veterinary Research

|April 1, 1977

Summary

A new tonography procedure in dogs was established. This study found reduced aqueous humor outflow in glaucomatous Beagles, indicating impaired fluid drainage in canine glaucoma.

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Area of Science:

Veterinary Ophthalmology
Animal Physiology

Background:

Tonography is crucial for assessing aqueous humor dynamics.
Canine glaucoma research requires reliable diagnostic methods.
Understanding intraocular pressure regulation is vital in veterinary medicine.

Purpose of the Study:

To establish a standardized tonography procedure in dogs.
To evaluate the effects of various anesthetics on tonography measurements.
To determine aqueous humor outflow in normal and glaucomatous Beagles.

Main Methods:

Developed and validated a tonography protocol for canine eyes.
Administered sedatives (acepromazine, ketamine, xylazine, droperidol-fentanyl) and combinations.
Performed Schiotz tonography for 4 minutes on each eye to measure intraocular pressure and outflow.

Main Results:

The combination of acepromazine and ketamine provided adequate restraint and anesthesia.
Normal Beagles exhibited a mean aqueous humor outflow coefficient of 0.24 mul/mm Hg/minute.
Glaucomatous Beagles showed a significantly lower mean outflow coefficient (0.09 mul/mm Hg/minute), with older dogs having reduced outflow.

Conclusions:

A reliable tonography procedure was successfully developed for dogs.
Aqueous humor outflow is significantly impaired in Beagles with glaucoma.
Age and glaucoma negatively impact aqueous humor dynamics in Beagles.

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