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Related Concept Videos

Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential.
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Plasticity00:58

Plasticity

Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.

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Articles linked to this work by shared authors, journal, and citation graph.

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[SOD1 gene mutations in patients with amyotrophic lateral sclerosis: potential for the method of molecular].

Molekuliarnaia biologiia·2014
Same author

Quantal analysis suggests strong involvement of presynaptic mechanisms during the initial 3 h maintenance of long-term potentiation in rat hippocampal CA1 area in vitro.

Brain research·2002
Same author

Postsynaptic hyperpolarization increases the strength of AMPA-mediated synaptic transmission at large synapses between mossy fibers and CA3 pyramidal cells.

Neuropharmacology·2000
Same author

Intracellular studies of the interaction between paired-pulse facilitation and the delayed phase of long-term potentiation in the hippocampus.

Neuroscience and behavioral physiology·1999
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Long-term synaptic changes induced by intracellular tetanization of CA3 pyramidal neurons in hippocampal slices from juvenile rats.

Neuroscience·1999
Same author

[Intracellular study of interaction of paired-pulse facilitation and late phase of hippocampal long-term potentiation].

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova·1998

Related Experiment Video

Updated: Jul 11, 2026

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
11:56

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Published on: November 11, 2017

[A mathematical model of neuronal plasticity]

Iu Z Saakian, A V Rossokhin, L E Tsitolovskiĭ

    Biofizika
    |May 1, 1993
    PubMed
    Summary

    This study introduces a novel neuron model that learns with a teacher using hypothetical chemical processes. The model effectively classifies distinct input images, demonstrating its learning capability.

    Area of Science:

    • Computational neuroscience
    • Artificial intelligence

    Context:

    • Developing biologically plausible computational models of neural function.
    • Exploring machine learning algorithms inspired by biological neural networks.

    Purpose:

    • To propose a novel neuron model capable of supervised learning.
    • To investigate the computational capacity of this model based on chemical processes.

    Summary:

    • A neuron model is presented, simulating hypothetical chemical processes found in real nerve cells.
    • This model, with O(N^2) memory elements, demonstrates the ability to classify distinct input images into two categories.
    • The classification capacity scales with the dimensionality (N) of the input vector, also as O(N^2).

    Impact:

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    • Provides a new framework for biologically inspired artificial intelligence.
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    • Potential applications in developing more sophisticated learning algorithms and neural prosthetics.