Hyperplasia of Brunner's glands of the duodenum

Hyperplasia of Brunner's glands is a rare phenomenon. It may cause obstructive symptoms, anemia or the patient may be totally asymptomatic. The diagnosis can be confirmed with endoscopic examination and upper gastrointestinal series. The surgical treatment or hyperplasia of the Brunner's glands should be conservative since the lesion is not premalignant. If complications do occur, local excision is the treatment of choice. Two patients are reported who had Brunner gland hyperplasia as an incidental finding at exploration for pancreatic pseudocyst, and a brief review of the literature is made.