Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell cycle checkpoints, genetic instability and cancer

T Weinert1, D Lydall

  • 1Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721.

Seminars in Cancer Biology
|April 1, 1993
PubMed
Summary

Cell cycle checkpoints maintain event order and detect DNA damage, crucial for preventing cancer. Understanding these checkpoints, including p53, offers new cancer treatment strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decreased cerebral Irp-1B limits impact of social isolation in wild type and Alzheimer's disease modeled in Drosophila melanogaster.

Genes, brain, and behavior·2017
Same author

The replication fork's five degrees of freedom, their failure and genome rearrangements.

Current opinion in cell biology·2009
Same author

A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae.

Genetics·2008
Same author

Details and concerns regarding the G2/M DNA damage checkpoint in budding yeast.

Cold Spring Harbor symposia on quantitative biology·2003
Same author

Quantitative amplification of single-stranded DNA (QAOS) demonstrates that cdc13-1 mutants generate ssDNA in a telomere to centromere direction.

Nucleic acids research·2001
Same author

Closing the gaps among a web of DNA repair disorders.

BioEssays : news and reviews in molecular, cellular and developmental biology·2000

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Cell cycle progression is regulated by checkpoints to ensure fidelity.
  • DNA damage checkpoints are critical for genomic stability.
  • Genetic instability in checkpoint mutants is linked to cancer development.

Purpose of the Study:

  • To explore the role of cell cycle checkpoints in maintaining genomic stability.
  • To investigate the mechanistic link between checkpoints, p34CDC2, and cancer.
  • To examine the involvement of the p53 protein in checkpoint function and cancer.

Main Methods:

  • Review of existing literature on cell cycle control and cancer.
  • Analysis of checkpoint mechanisms in normal and cancer cells.
  • Hypothesizing the impact of mutations in cell cycle and DNA metabolism genes on checkpoint function.

Main Results:

  • Two DNA damage-sensitive checkpoints exist: one before mitosis and one before DNA replication.
  • Checkpoint dysfunction is associated with genetic instability, a hallmark of cancer.
  • p34CDC2 and its regulators are mechanistically linked to checkpoint control.
  • The p53 protein likely functions at the G1-S checkpoint.

Conclusions:

  • Cell cycle checkpoints, particularly those sensitive to DNA damage, are vital in preventing cancer.
  • Mutations affecting cell cycle regulators and DNA metabolism can impair checkpoint function.
  • Targeting checkpoints, including the p53 pathway, may offer novel cancer therapeutic approaches.

Related Experiment Videos