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Arterial hypertension and cardiovascular damage in the elderly: focus on arterial stiffness and left ventricular

E Paciaroni1, R Antonicelli, C Gambini

  • 1Centro di Patologia Cardiovascolare e dell'Ipertensione Arteriosa, Istituto I.N.R.C.A. (Italian National Research Centre on Aging), Ancona, Italy.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|January 1, 1993
PubMed

Insights

Aging and Arterial Hypertension (AH) both induce cardiovascular changes. This study examines how these factors impact aortic distensibility and left ventricular hypertrophy for clinical significance.

Area of Science:

  • Cardiovascular Physiology
  • Gerontology
  • Hypertension Research

Background:

  • Aging and Arterial Hypertension (AH) induce significant cardiovascular structural and functional alterations.
  • Reduced aortic distensibility (RAD) and left ventricular hypertrophy (LVH) are key indicators of cardiovascular damage.
  • These changes contribute to widespread morphological alterations in the cardiovascular system.

Purpose of the Study:

  • To analyze the combined effects of aging and AH on the cardiovascular apparatus.
  • To investigate the clinical significance of RAD and LVH in the context of aging and hypertension.
  • To understand the interplay between aging, hypertension, and cardiovascular remodeling.

Main Methods:

  • Review and analysis of existing literature on aging and cardiovascular changes.
  • Examination of studies focusing on Arterial Hypertension and its cardiovascular impact.
  • Correlation analysis between aging parameters, AH severity, RAD, and LVH.

Main Results:

  • Both aging and AH independently contribute to reduced aortic distensibility.
  • Left ventricular hypertrophy is a common consequence of both aging and sustained Arterial Hypertension.
  • The combination of aging and AH exacerbates cardiovascular damage markers like RAD and LVH.

Conclusions:

  • RAD and LVH are critical clinical markers reflecting cardiovascular damage from aging and AH.
  • Understanding these markers is crucial for assessing cardiovascular risk in aging hypertensive populations.
  • Further research is warranted to explore therapeutic strategies targeting RAD and LVH in this demographic.

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