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The results of a targeted pharmacy intervention program

J J Schentag1

  • 1Department of Pharmacy and Pharmaceutics, State University of New York, Buffalo.

Clinical Therapeutics
|January 1, 1993
PubMed
Summary

Pharmacy intervention successfully reduced ceftazidime use, leading to the reversion of Enterobacter species

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Area of Science:

  • Clinical Pharmacy
  • Infectious Diseases
  • Microbiology

Background:

  • Rising resistance to ceftazidime and other beta-lactam antibiotics in Enterobacter species was observed.
  • Increased ceftazidime usage correlated with the development of antibiotic resistance.

Purpose of the Study:

  • To assess the impact of pharmacy intervention on antibiotic resistance patterns.
  • To evaluate the effectiveness of restricting ceftazidime use.

Main Methods:

  • Implemented severe restrictions on ceftazidime use via pharmacy intervention.
  • Substituted ceftazidime with tobramycin plus piperacillin for severe infections.
  • Monitored Enterobacter species' susceptibility patterns.

Main Results:

  • Enterobacter susceptibility to ceftazidime returned to baseline within 3 months.
  • Ceftazidime use decreased by 98% from its peak.
  • No enhanced resistance developed against tobramycin, piperacillin, or other formulary antibiotics.

Conclusions:

  • Active pharmacy intervention effectively reversed antibiotic resistance in Enterobacter species.
  • Restriction of beta-lactam antibiotic use can restore susceptibility.
  • This strategy prevented cross-resistance development.

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