A three compartment open model with two time lags

The present study deals with the identification of exchange parameters involved in a three-compartment open model with two time lags in which elimination occurs from the central compartment. Two different optimization methods have been used which involve the reduction of different unknowns to a single variable theta, with the help of Archimedes Spiral. Thus, the solution requires the global minimum of a functional of single variable theta. Results are compared with those obtained by the generalized least square method.