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Related Experiment Videos

Acute adrenocortical failure due to tuberculosis

F Keleştimur1, O Ozbakir, A Sağlam

  • 1Department of Internal Medicine, Erciyes University, Medical School, Kayseri Turkey.

Journal of Endocrinological Investigation
|April 1, 1993
PubMed
Summary

Tuberculosis can cause acute adrenal failure, not just chronic insufficiency. Surgical removal of an adrenal tuberculoma confirmed this rare presentation in a 55-year-old woman.

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Area of Science:

  • Endocrinology
  • Infectious Diseases
  • Pathology

Background:

  • Tuberculosis (TB) is a significant global health concern.
  • Adrenal insufficiency, or Addison's disease, typically results from autoimmune destruction or hemorrhage.
  • Tuberculous involvement of the adrenal glands is a known but less common cause of adrenal insufficiency.

Observation:

  • A 55-year-old woman presented with symptoms of acute adrenal failure.
  • She had coexisting active pulmonary tuberculosis and a noticeable enlarged adrenal mass.
  • The adrenal mass was surgically removed for examination.

Findings:

  • Histopathologic examination revealed the adrenal mass to be an adrenal tuberculoma.
  • This finding directly links the tuberculosis infection to the adrenal pathology.

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  • The case demonstrates a direct causal relationship between adrenal tuberculoma and acute adrenal failure.

    • Implications:

    • This case highlights that tuberculosis can manifest as acute adrenal failure, a severe and potentially life-threatening condition.
    • Adrenal tuberculoma should be considered in the differential diagnosis of adrenal masses, especially in patients with a history of tuberculosis.
    • Early diagnosis and appropriate treatment of adrenal tuberculosis are crucial to prevent acute adrenal crisis and manage adrenocortical insufficiency.