Plasma endothelin-1 concentration in the inferior turbinate

Endothelin (ET)-1 has the most potent vasocontrictive action of any substance known to date. Three milliliters of blood was removed from both the inferior turbinate and from the antecubital vein of six patients who underwent nasal surgery under general anesthesia. After centrifugation of the blood samples, the plasma was sent for radioimmunoassay of the plasma levels of ET-1. The plasma ET-1 level in the nasal blood vasculature was 6.4 +/- 1.0 pg/mL (mean +/- SEM), which was almost equivalent to that found in the antecubital vein (5.3 - 2.7 pg/mL) (N = 6). These values were greater than the normal range (1.5 +/- 0.5 pg/mL) probably because of the effect of general anesthesia. These results indicate that ET-1 is present in similar levels in the blood vessels of the inferior turbinate and the antecubital vein. A hypothesis that adrenaline induces ET production was not confirmed because topically applied adrenaline did not raise the plasma ET-1 level either in the nasal vasculature or in the peripheral vein.