Related Experiment Videos
[Optimal glucose dose in the preoperative fluid infusion]
1Department of Anesthesia, Chubu Rosai Hospital, Nagoya.
Masui. the Japanese Journal of Anesthesiology
|May 1, 1993
Summary
Optimal preoperative glucose infusion for surgical patients is 0.4-0.5 g.kg-1. This dose maintains energy metabolism during fasting, preventing both hyperglycemia and hypoglycemia in patients undergoing afternoon laparotomy.
Area of Science:
- Metabolic research
- Clinical nutrition
- Surgical patient care
Context:
- Preoperative fasting is essential but can disrupt patient energy metabolism.
- Maintaining stable blood glucose levels is critical for surgical outcomes.
- Previous glucose dosing strategies lacked clear evidence for optimal levels.
Purpose:
- To determine the optimal glucose dose for preoperative fluid infusion.
- To assess the impact of varying glucose doses on metabolic markers (3-OHBA, NEFA, lactate).
- To identify glucose administration levels that prevent hypoglycemia and hyperglycemia in fasting surgical patients.
Summary:
- Blood concentrations of glucose, 3-hydroxybutyrate (3-OHBA), non-esterified fatty acid (NEFA), and lactate were measured in 105 patients before and after glucose administration.
- Glucose doses >0.4 g.kg-1 suppressed 3-OHBA production, while doses <0.2 g.kg-1 led to hypoglycemia and doses >0.5 g.kg-1 to hyperglycemia.
- A preoperative glucose infusion of 0.4-0.5 g.kg-1 was found to be optimal for maintaining energy metabolism during fasting.
Impact:
- Provides evidence-based guidance for preoperative glucose management in surgical patients.
- Helps clinicians optimize fluid therapy to prevent adverse metabolic events during fasting.
- Contributes to improved patient safety and perioperative metabolic control.