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[Antimicrobial susceptibility patterns of the Proteeae in Japan, 1989]
Abstract:
We discussed the antimicrobial susceptibilities of Proteeae isolated in Japan, 1989. Eight hundred six clinical isolates were collected from 47 hospitals. These were comprised of 431 strains of Proteus mirabilis, 155 Proteus vulgaris, 154 Morganella morganii, 44 Providencia rettgeri and 22 Providencia stuartii. Antibiotics tested in this study were 2 penicillins, 5 cephems, 1 carbapenem and 2 aminoglycosides. The MIC's were determined using the standard method of the Japan Society of Chemotherapy. Susceptibilities of the above strains to these antibiotics are described below; 1. Latamoxef, ceftizoxime and imipenem had excellent activities with no evident differences among the species of Proteeae. 2. Ampicillin and cefazolin were less active against Indol-positive Proteeae. 3. Piperacillin and cefmetazole were also strongly active drugs against P. mirabilis, P. vulgaris and P. stuartii, and cefotiam against P. mirabilis and P. stuartii. 4. Gentamicin and netilmicin showed excellent activities against M. morganii.
Insights
Antimicrobial susceptibility testing of Proteeae bacteria in Japan revealed that latamoxef, ceftizoxime, and imipenem showed excellent activity against most species. Gentamicin and netilmicin were effective against Morganella morganii.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Context:
- The Proteeae tribe, including genera like Proteus, Morganella, and Providencia, are significant human pathogens.
- Understanding their antimicrobial resistance patterns is crucial for effective treatment strategies.
- This study provides data from clinical isolates collected across Japan in 1989.
Purpose:
- To evaluate the antimicrobial susceptibilities of various Proteeae species isolated from clinical samples in Japan.
- To compare the efficacy of different antibiotic classes, including penicillins, cephems, carbapenems, and aminoglycosides, against these bacteria.
Summary:
- Eight hundred six clinical isolates of Proteeae (Proteus mirabilis, Proteus vulgaris, Morganella morganii, Providencia rettgeri, Providencia stuartii) were tested against 10 antibiotics.
- Latamoxef, ceftizoxime, and imipenem demonstrated broad-spectrum activity across Proteeae species.
- Ampicillin and cefazolin showed reduced activity against indole-positive strains, while piperacillin, cefmetazole, cefotiam, gentamicin, and netilmicin displayed species-specific efficacy.
Impact:
- The findings highlight the effectiveness of certain newer antibiotics like imipenem and third-generation cephalosporins against Proteeae infections.
- This data can inform empirical antibiotic therapy choices for infections caused by these Gram-negative bacteria.
- The study underscores the importance of ongoing surveillance of antimicrobial resistance patterns in clinical settings.