Related Experiment Videos
Fibrodysplasia ossificans progressiva and synovial chondromatosis
G Kalifa1, C Adamsbaum, C Job-Deslande
1Hôpital Saint Vincent de Paul, Paris, France.
Insights
Two children with rare fibrodysplasia ossificans progressiva and synovial chondromatosis highlight a potential genetic link. This G protein-related hypothesis may explain the unusual co-occurrence of these bone and cartilage disorders.
Area of Science:
- Medical Genetics
- Orthopedics
- Developmental Biology
Background:
- Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by progressive ectopic ossification.
- Synovial chondromatosis is a benign cartilaginous tumor arising from the synovial membrane.
- The co-occurrence of FOP and synovial chondromatosis is exceptionally rare.
Abstract:
Two cases of an unusual association-fibrodysplasia ossificans progressiva and synovial chondromatosis-in non-related children are presented. This association does not seem coincidental and raises several questions about the pathogenesis. A genetic hypothesis related to G proteins is proposed. This is supported by the fact that such abnormalities have been demonstrated in pseudohypoparathyroidism and fibrous dysplasia; these diseases can also be associated with fibrodysplasia ossificans progressiva.