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Chronic treatment with valproate decreases the hypothermic response to clonidine
S C Dilsaver1, D Minkus, A C Swann
1Department of Psychiatry and Behavioral Sciences, University of Texas, Houston 77021.
Pharmacology, Biochemistry, and Behavior
|May 1, 1993
Abstract:
Treatment with lithium (the prototype of an antimanic agent) attenuates responsiveness to the alpha 2-agonist clonidine in animal models. Valproate is now used to treat mania. The effect of treatment with this drug on responses mediated by an alpha 2-agonist have yet to be reported. The authors assessed the effect of a 14-day course of orally administered valproate on the rat's hypothermic response to clonidine. Treatment with valproate decreased this response.