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[Serum CA125 measurement is useful in 3 cases with pericardial effusion]
S Toshihiko1, U Megumi, H Takahiro
1Medical Department, Osaka Nakatsu Saiseikai Hospital.
Insights
Serum cancer antigen 125 (CA125) levels can effectively monitor pericardial effusion. Elevated CA125 indicates effusion presence and aids in assessing treatment response and clinical status.
Area of Science:
- Cardiology
- Oncology
- Clinical Chemistry
Background:
- Serum cancer antigen 125 (CA125) is often elevated in patients with pericardial effusion.
- The utility of CA125 in monitoring the clinical course of pericardial effusion requires further investigation.
Abstract:
Previously we reported that serum CA125 level is elevated in cases of pericardial effusion. We report three cases in which serum CA125 measurement is useful for assessing clinical status. In case 1, a 19-year-old came to our hospital for cardiac tamponade. Moderate degree of pericardial effusion and high CA125 level were observed. After the pericardectomy the serum CA125 level was normalized and pericardial effusion disappeared. Case 2, a 50-year-old man with mesothelioma and in whom serum CA125 level was elevated with pericardial effusion. After cardiac drainage his condition improved, with decreased CA125 level. However, later the CA125 level rose and recurrent localized pericardial effusion with worsening condition was observed. In case 3, in a 78-year-old woman with pericardial effusion no recurrence was observed after pericardial drainage. Her CA125 value was normal. These results indicated that measurement of CA125 value is a useful marker for assessing the clinical course of this disease.