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[Antiphospholipid antibodies and cerebral ischemic infarction in a 6-year-old boy]
R R Forastiero1, C Falcón, S Rodrigué
1Sección Hemostasia y Trombosis, Hospital de Clínicas, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
Insights
Anti-phospholipid antibodies (aPL) were detected in a child with cerebral ischemia. This suggests aPL may contribute to childhood arterial thrombosis, warranting systematic screening.
Area of Science:
- Pediatric Neurology
- Immunology
- Hematology
Background:
- Thrombosis in children is a significant clinical concern.
- Anti-phospholipid antibodies (aPL) are linked to thrombosis in adults.
Observation:
- A six-year-old child presented with cerebral ischemic infarction.
- The child had lupus anticoagulant activity and aPL.
- No underlying conditions were identified.
Findings:
- The presence of aPL in a pediatric case of arterial thrombosis.
- Potential role of aPL in childhood arterial thrombotic events.
Implications:
- Suggests aPL should be systematically investigated in children with arterial thrombosis.
- Highlights the need to consider autoimmune factors in pediatric stroke.
- May inform diagnostic and therapeutic strategies for childhood thrombosis.
Abstract:
Lupus anticoagulant activity and anti-phospholipid antibodies (aPL) were found in a six-year-old child with cerebral ischemic infarction in the absence of any underlying disease. The association of these antibodies with thrombosis has been well documented in adult patients. In view of our observation, we believe that aPL may also be involved in the pathogenesis of arterial thrombotic events in childhood, and aPL should be systematically searched in these cases.