Related Experiment Videos
Effects of structural modifications of ether lipids on antiproliferative activity against human glioma cell lines
M E Berens1, E Bar-Shira, M L Rosenblum
1Department of Neurological Surgery, School of Medicine, University of California, San Francisco 94143.
Abstract:
The effect of structural modifications of ether lipids on antiproliferative activity was studied in four human glioma cell lines. Drug potency, determined by microtetrazolium assay, varied 7- to 30-fold. CP 46,665 was most potent; Amido-18-OEt was least potent. Antiproliferative activity was highly dependent on drug exposure time. Except for CP 46,665, which reached maximal activity after 2 hr, 40 microM ether lipids were effective only after 24 hr. Structural modifications of ether lipids can increase their potency and reduce the time required for antiproliferative activity. Ether lipid analogs may be useful for treating human gliomas.