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Gamma radiation-induced differentiation on human neuroblastoma cells in culture
P Rocchi1, A M Ferreri, G Simone
1Istituto di Cancerologia, Università di Bologna, Italy.
Anticancer Research
|March 1, 1993
Abstract:
We have studied the effect of gamma radiation on differentiation in neuroblastoma cell lines AF8 and SJ-N-KP. Growth inhibition and morphological and biochemical differentiation have been examined following radiation exposure to 1-10 Gy. Gamma radiation induced marked growth inhibition and morphological differentiation in a dose-and time-dependent manner in both cell lines, and induced biochemical differentiation in AF8 cells.