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Ciprofloxacin for treatment of severe typhoid fever in children
Insights
Intravenous ciprofloxacin effectively treated severe typhoid fever in children, achieving a 94.4% cure rate. This antibiotic regimen led to rapid recovery, with no observed complications or relapses in the study group.
Area of Science:
- Pediatric Infectious Diseases
- Antimicrobial Therapy
- Tropical Medicine
Background:
- Severe typhoid fever poses a significant health threat to children globally.
- Multiresistant Salmonella typhi strains complicate treatment options.
- Intravenous antibiotic therapy is crucial for severe pediatric infections.
Purpose of the Study:
- To evaluate the efficacy and safety of intravenous ciprofloxacin in treating severe typhoid fever in children.
- To assess the clinical cure rate and eradication of multiresistant Salmonella typhi.
- To monitor recovery time and identify any adverse events or complications.
Main Methods:
- A cohort of 18 children with confirmed severe typhoid fever received intravenous ciprofloxacin (10 mg/kg/day).
- Clinical outcomes, including cure, fever resolution, and consciousness recovery, were meticulously recorded.
- Patients were monitored for complications, relapse, and carrier state over a 3-month follow-up period.
Main Results:
- A high clinical cure rate of 94.4% (17/18 patients) was achieved.
- Eradication of multiresistant Salmonella typhi infection was confirmed in the cured patients.
- Children showed rapid improvement, with normal consciousness regained in an average of 2 days and normal temperature in 3.3 days.
- No complications, relapses, or carrier states were observed during the study and follow-up.
Conclusions:
- Intravenous ciprofloxacin is a highly effective and safe treatment for severe typhoid fever in children.
- The treatment facilitates rapid clinical recovery and successful eradication of multiresistant Salmonella typhi.
- This regimen offers a promising therapeutic option, minimizing the risk of complications and long-term sequelae.
Abstract:
Eighteen children with bacteriologically confirmed severe typhoid fever were initially treated intravenously with ciprofloxacin (10 mg/kg of body weight per day). Clinical cure with eradication of multiresistant Salmonella typhi infection was observed in 17 patients (94.4%; 95% confidence interval [CI], 84 to 100%). Children regained normal consciousness within an average of 2 days (95% CI, 1.8 to 2.2 days). The temperatures of the children returned to normal within 3.3 days (95% CI, 3.1 to 3.5 days). Complications were not observed during the hospital stay or a 3-month follow-up period. Relapse and carrier state were also not encountered during the follow-up period.