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Antimicrobial resistance of Salmonella isolates in a Spanish hospital
P Muńoz1, M D Díaz, M Rodríguez-Créixems
1Servicio de Microbiología Clínica, Hospital General Gregorio Marañón, Madrid, Spain.
Abstract:
We studied 961 clinical Salmonella isolates (one per patient) seen in one Spanish hospital from 1988 to 1991. The incidence of non-Salmonella typhi Salmonella infections per 100,000 admissions increased from 3.93 to 5.98. Overall rates of resistance to ampicillin, chloramphenicol, and co-trimoxazole were 32, 11, and 2%, respectively. Resistance to chloramphenicol increased from 9 to 16% during the study period, while resistance to each of the other drugs remained stable. Variations related to serogroups were observed.
Insights
Salmonella infections, excluding Salmonella typhi, rose in Spain between 1988-1991. Chloramphenicol resistance in Salmonella isolates significantly increased during this period.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Salmonella infections represent a significant public health concern.
- Understanding trends in Salmonella incidence and antimicrobial resistance is crucial for effective treatment and public health strategies.
Purpose of the Study:
- To analyze the incidence of non-Salmonella typhi Salmonella infections.
- To determine antimicrobial resistance patterns for common antibiotics in Salmonella isolates.
- To observe changes in resistance over a defined study period.
Main Methods:
- Retrospective analysis of 961 clinical Salmonella isolates from a Spanish hospital (1988-1991).
- Calculation of incidence rates per 100,000 admissions.
- Antimicrobial susceptibility testing for ampicillin, chloramphenicol, and co-trimoxazole.
Main Results:
- Incidence of non-Salmonella typhi Salmonella infections increased from 3.93 to 5.98 per 100,000 admissions.
- Overall resistance rates: ampicillin (32%), chloramphenicol (11%), co-trimoxazole (2%).
- Chloramphenicol resistance rose from 9% to 16% during the study, while resistance to ampicillin and co-trimoxazole remained stable. Serogroup-specific variations were noted.
Conclusions:
- Non-typhoidal Salmonella infections showed an increasing incidence in the studied Spanish population.
- A concerning rise in chloramphenicol resistance among Salmonella isolates was observed.
- Antimicrobial resistance patterns in Salmonella are dynamic and may vary by serogroup, necessitating ongoing surveillance.