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Peripheral arterial thrombolysis: intermediate-term results

R J Lonsdale1, S C Whitaker, D C Berridge

  • 1Department of Vascular Surgery, University Hospital, Nottingham, UK.

The British Journal of Surgery
|May 1, 1993
PubMed
Summary
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Intra-arterial thrombolysis shows good intermediate-term results when successful within 30 days. Successful treatment leads to sustained arterial patency and limb salvage in most patients.

Area of Science:

  • Vascular Surgery
  • Interventional Radiology
  • Cardiovascular Medicine

Background:

  • Intra-arterial thrombolysis is a critical treatment for acute limb ischemia.
  • Understanding the intermediate-term outcomes is essential for patient management and treatment planning.

Purpose of the Study:

  • To evaluate the intermediate-term results of intra-arterial thrombolysis.
  • To assess the patency rates and limb salvage following successful thrombolysis.

Main Methods:

  • Retrospective review of 129 consecutive intra-arterial thrombolysis courses in 127 patients.
  • Median follow-up duration of 3 years.
  • Assessment of thrombolysis success at 30 days, patency, reocclusion, and limb outcomes.

Main Results:

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  • Successful thrombolysis was achieved in 49% of cases (63/129).
  • Among successful cases, estimated arterial patency rates were 80% at 1 year, 72% at 2 years, and 70% at 3 years.
  • Intermediate-term results were significantly worse for unsuccessful thrombolysis cases (24% limb salvage).

Conclusions:

  • Successful intra-arterial thrombolysis yields good intermediate-term results with high patency and limb salvage rates.
  • Treatment success at 30 days is a key predictor of favorable long-term outcomes.