[Review of Kleine-Levin syndrome: toward an integrated approach]

Kleine-Levin syndrome is a characterized by a periodic hypersomnia crisis as well as dietary and variable significant psychic symptoms. Its rarity makes its definition and study complex. Many etiologies have been considered, especially regarding a hypothalamic dysfunction. Physiological, radiologic, anatomical and polysomnographic studies have not shown clearly conclusive results, but the syndrome appears to be related to affective disorders. This hypothesis is supported by the findings of a positive therapeutic response to lithium. However, we are interested in the related psychological factors, whether they are primary or secondary. A clinical case illustrates these factors, and a basic neuropsychiatric intervention concept is proposed.