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Radiological presentations of Castleman's disease
Y Yamashita1, T Hirai, T Matsukawa
1Department of Radiology, Kumamoto University School of Medicine, Japan.
Insights
Radiographic imaging reveals characteristic features of hyaline vascular Castleman's disease. These findings aid in diagnosing this rare lymphoproliferative disorder.
Area of Science:
- Radiology
- Oncology
- Pathology
Background:
- Castleman's disease is a rare lymphoproliferative disorder.
- Hyaline vascular Castleman's disease is the most common subtype.
- Accurate diagnosis relies on characteristic imaging findings.
Observation:
- Three cases of hyaline vascular Castleman's disease were analyzed.
- Imaging modalities included CT, angiography, sonography, and MR imaging.
- Tumors presented as homogeneous masses with specific enhancement patterns.
Findings:
- CT showed homogeneous masses with marked contrast enhancement.
- Angiography revealed hypervascularity with prominent tumor blush.
- Sonography demonstrated hypoechoic masses with hyperechoic spots.
- MR imaging showed homogeneous architecture, hypointense on T1, hyperintense on T2.
- Calcification and lymphadenopathy were noted in some cases.
Implications:
- Characteristic imaging findings support Castleman's disease diagnosis.
- Inclusion in differential diagnosis is crucial for tumors in lymphoid tissue areas.
- Multimodality imaging aids in differentiating Castleman's disease.
Abstract:
The radiographic appearances of three cases of Castleman's disease of hyaline vascular type are reported. CT demonstrated homogeneous masses with marked contrast enhancement. Calcification was seen in one, and associated lymphadenopathy was seen in two. All tumors were hypervascular with prominent tumor blush on angiography. Sonography showed the masses to be hypoechoic with hyperechoic spots. On MR imaging, all tumors had homogeneous architecture with hypointensity on T1-weighted images and hyperintensity on T2-weighted images. In tumors with above characteristics in areas where lymphoid tissue is normally found, Castleman's disease should be added to the list of differential diagnosis.