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Neuronal plasticity and function

W H Gispen1

  • 1Rudolf Magnus Institute, Utrecht, The Netherlands.

Clinical Neuropharmacology
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Neuronal plasticity, the brain

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Area of Science:

  • Neuroscience
  • Cellular Biology
  • Neurobiology

Background:

  • Neuronal plasticity is the nervous system's ability to adapt throughout life.
  • It involves development, degeneration, and regeneration processes.
  • Intracellular calcium ([Ca2+]) is crucial for neuronal function, particularly in growth cones and synaptic plasticity.

Purpose of the Study:

  • To explore the role of intracellular calcium ([Ca2+]) in neuronal plasticity.
  • To investigate how calcium homeostasis is affected during aging.
  • To examine the potential benefits of nimodipine in mitigating age-related functional decline.

Main Methods:

  • Review of current research on neuronal plasticity, growth cones, and synaptic plasticity.
  • Discussion of the impact of altered calcium ([Ca2+]) homeostasis on neuronal function.

Related Experiment Videos

  • Consideration of studies on aged rats treated with the L-channel calcium blocker nimodipine.

    • Main Results:

    • Intracellular calcium ([Ca2+]) levels significantly influence neurite outgrowth and synaptic plasticity.
    • Aging can lead to subtle disturbances in calcium ([Ca2+]) homeostasis, potentially causing functional loss.
    • Chronic nimodipine treatment showed beneficial effects on sensorimotor function in aged rats.

    Conclusions:

    • Calcium ([Ca2+]) regulation is fundamental to neuronal plasticity across the lifespan.
    • Age-related calcium ([Ca2+]) dysregulation may underlie functional deficits.
    • Nimodipine's protective effects suggest a therapeutic avenue for age-related neurological decline.